Coronavirus discussion thread

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sallykate Feb 2021 7:37pm, 2 Feb 2021 7,525 posts	0 sallykate The only issue with the AZ trial is not enough data in over-65s. There are good reasons for that. - they focused on recruiting younger people first so that they had a good sense of safety - that meant that there were fewer over-65s in the trial than in other companies' trials at the endpoint. So much of this is down to protocol design. The good news seems to be that there's a decent transmission reduction from the AZ vaccine (not something that all trials were monitoring).
simbil Feb 2021 7:45pm, 2 Feb 2021 9,195 posts	0 simbil Sounds like some very good indications about AZ reducing transmission.
anthonyj89 Feb 2021 8:09pm, 2 Feb 2021 151 posts	0 anthonyj89 ONS data tests prevalence rather than incidence. Apples and oranges compared with ZOE.
K5 Gus Feb 2021 8:10pm, 2 Feb 2021 4,346 posts	0 K5 Gus It seems a very strange trial protocol design though don't you think. It was known from day 1 that the elderly were most at risk, and therefore who needed the vaccine most, so why would you not include enough of them to prove statistical significance ?
Bazoaxe Feb 2021 8:18pm, 2 Feb 2021 18,834 posts	0 Bazoaxe I think its safer to test in younger and healthier people first who if there was a reaction would have most chance of fighting it off
ThorntonRunner Feb 2021 8:36pm, 2 Feb 2021 4,561 posts	0 ThorntonRunner I'd agree with Baz - would be a safety issue.
MsG Feb 2021 8:40pm, 2 Feb 2021 1,802 posts	0 MsG I haven't been outside on my bike since November because 1. Last time I talked to another cyclist who was cheerfully detailing me all the ways in which lockdown hadn't affected his life (meeting up with mtbers 8+ group at weekend, daughter travelling back and forth from uni etc in another city) 2. The literal interpretation of local area = city means a 7 x 4 mile area to cycle in, bounded by busy A road and very muddy single-track or suburban roads lined with parked cars and pedestrians who have a death wish 3. The persistent heavy rain = very muddy trails 4. Worried about people having a go at me for being out So I've stuck to my indoor trainer.
K5 Gus Feb 2021 8:50pm, 2 Feb 2021 4,347 posts	0 K5 Gus I thought the idea of a trial was to prove it worked against the target population ?
Bazoaxe Feb 2021 8:55pm, 2 Feb 2021 18,836 posts	0 Bazoaxe Yeah so once they know there is no reaction they start to widen it out more.
HappyG(rrr) Feb 2021 10:03pm, 2 Feb 2021 37,473 posts	0 HappyG(rrr) Germany and EU have changed their advice /decision re AZ and O65s I think. Will try and find link. Was within about 3 days of original decision. Iirc.